Bioactive Polymers 62. A Novel Macromolecular Drug Based on 5-Acetylamino-2-Sulfamoyl-1,3,4 Thiodiazole
Abstract The condensation reaction of 5-acetylamino-2-sulfamoyl-1,3,4 thiodiazole (acetazolamide) on the poly(acrylic acid-co-styrene) copolymer was studied, with a view to obtaining a retard drug. Coupling was performed in a THF medium in the presence of dicyclohexylcarbodiimide as activator. The d...
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| Veröffentlicht in: | Drug development and industrial pharmacy 1990, Vol.16 (2), p.267-281 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Abstract
The condensation reaction of 5-acetylamino-2-sulfamoyl-1,3,4 thiodiazole (acetazolamide) on the poly(acrylic acid-co-styrene) copolymer was studied, with a view to obtaining a retard drug. Coupling was performed in a THF medium in the presence of dicyclohexylcarbodiimide as activator. The diuretic effect of the newly obtained drug was checked in rats. |
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| ISSN: | 0363-9045 1520-5762 |
| DOI: | 10.3109/03639049009114885 |