Inhibition of collagen cross-linking: A new approach to ocular scarring

A method for the production of alkali-induced conjunctival scarring in rabbits with minimal corneal involvement is presented. The lathyritic agent BETA-AMIN0PR0PI0NITRILE (BAPN), an inhibitor of collagen cross-linking, was applied topically for a period of 21 days after induction of injury. There wa...

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Veröffentlicht in:	Current eye research 1981, Vol.1 (2), p.77-84
1. Verfasser:	Moorhead, Louise Cope
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopropionitrile - analogs & derivatives Aminopropionitrile - pharmacology Animals Cicatrix - prevention & control Collagen - biosynthesis Conjunctiva - drug effects Disease Models, Animal Rabbits Wound Healing - drug effects
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Zusammenfassung:	A method for the production of alkali-induced conjunctival scarring in rabbits with minimal corneal involvement is presented. The lathyritic agent BETA-AMIN0PR0PI0NITRILE (BAPN), an inhibitor of collagen cross-linking, was applied topically for a period of 21 days after induction of injury. There was a statistically significant (p
ISSN:	0271-3683 1460-2202
DOI:	10.3109/02713688109001730