The Peptic Gastric Ulcer - Histotopographic and Functional Investigations

Histotopographic studies of approximately 200 gastric ulcers using endoscopic biopsies show that the chronic gastric ulcer is found in mucosa containing only mucoid or intestinal glands. Furthermore, with few exceptions (prepyloric ulcer), this mucosa is usually inflamed. Since the ulcer is nearly always found at the border to the acid-producing mucosa, the localization is an indication of the extent of gastritis and of the maximal acid secretion capacity of the stomach. In patients with a gastric ulcer, normal body or antrum mucosa is found more rarely than in a corresponding control group.