The effects of recombinant human erythropoietin given immediately after delivery to women with anaemia
SUMMARY Objective: Anaemia is a common problem during pregnancy and the puerperium. This study was designed to determine the efficacy and safety of giving recombinant human erythropoietin (EPO) to anaemic women during the puerperium. Method: Thirty-seven women received a single dose of EPO (20,000 I...
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Veröffentlicht in: | Current medical research and opinion 2003, Vol.19 (4), p.346-349 |
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Sprache: | eng |
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Zusammenfassung: | SUMMARY
Objective: Anaemia is a common problem during pregnancy and the puerperium. This study was designed to determine the efficacy and safety of giving recombinant human erythropoietin (EPO) to anaemic women during the puerperium.
Method: Thirty-seven women received a single dose of EPO (20,000 IU intravenously) immediately after delivery. A control population (n = 37) matched according to age and haemoglobin concentration was evaluated. All women received oral iron supplementation for 40 days after delivery. Haemoglobin concentrations were measured 4 and 40 days after delivery. Blood transfusions were given depending on clinical condition and haemoglobin level.
Results: Patients treated with EPO had a significantly higher mean haemoglobin concentration than control patients at days 4 and 40. No women in the EPO group required a transfusion, compared with six in the control group. No side-effects and fewer anaemia-related symptoms were observed during EPO treatment.
Conclusion: EPO given at delivery is effective in decreasing the need for blood transfusion and the incidence of problems associated with anaemia during the puerperium. |
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ISSN: | 0300-7995 1473-4877 |
DOI: | 10.1185/030079903125001802 |