DOPPLER ULTRASOUND SCREENING PREDICTS RECURRENCE OF POOR PREGNANCY OUTCOME IN SUBSEQUENT PREGNANCIES, BUT NOT THE RECURRENCE OF PIH OR PREECLAMPSIA

Objective: To assess the role of Doppler uterine artery screening in the prediction of recurring hypertensive disorders in a high-risk population. Methods: Ninety-four women with a history of hypertensive disorders in previous pregnancies underwent ultrasound color Doppler to analyze blood flow in the uterine arteries at 21-22 weeks of gestation. We evaluated the performance of the Pulsatility Index (PI) as well as the diastolic notch to predict recurring hypertensive disorders. Outcome measures were the recurrence of hypertensive disorders, and poor pregnancy outcome due to intrauterine death growth retardation, intrauterine death, placental abruption, hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome, eclampsia, or premature birth. Onset of symptoms was before 35 weeks in all cases of poor pregnancy outcome. Results: Doppler flow recordings were obtained from a well-defined location in both uterine arteries. The predictive value of the uterine artery PI for recurring hypertensive disease was poor and not significant; interestingly, however, the predictive values for poor pregnancy outcome were good (sensitivity 83% specificity 71% p < 0.001). The PI also provides a good test for intrauterine growth retardation (sensitivity 80% specificity 69% p < 0.01). The "diastolic notch" did not perform as well as the PI. Conclusions: Uterine artery screening did significantly predict the recurrence of poor pregnancy outcome due to hypertensive complications in this high-risk group. In contrast, gestational hypertension and preeclampsia with normal pregnancy outcome were not significantly predicted by uterine artery screening.