Synthesis and Antiviral Effect against Herpes Simplex Type 1 of 12-substituted Benzo[c]phenanthridinium Salts

The synthesis of benzo[c]phenanthridine alkaloid derivatives is described. In vitro antiviral activity against herpes simplex type 1 (HSV1) has been investigated. Contrary to the natural product fagaronine, which did not have any activity in the HSV1 antiviral tests, four 12-alkoxy derivatives showe...

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Veröffentlicht in:Journal of enzyme inhibition and medicinal chemistry 2004-12, Vol.19 (6), p.481-487
Hauptverfasser: Vanquelef, Enguerran, Amoros, Maryvonne, Boustie, Joel, Lynch, Michael A., Waigh, Roger D., Duval, Olivier
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Sprache:eng
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Zusammenfassung:The synthesis of benzo[c]phenanthridine alkaloid derivatives is described. In vitro antiviral activity against herpes simplex type 1 (HSV1) has been investigated. Contrary to the natural product fagaronine, which did not have any activity in the HSV1 antiviral tests, four 12-alkoxy derivatives showed good activity demonstrating the importance of the 12-substitution in the structure-activity relationships.
ISSN:1475-6366
1475-6374
DOI:10.1080/14756360412331280518