Synthesis and Antiviral Effect against Herpes Simplex Type 1 of 12-substituted Benzo[c]phenanthridinium Salts
The synthesis of benzo[c]phenanthridine alkaloid derivatives is described. In vitro antiviral activity against herpes simplex type 1 (HSV1) has been investigated. Contrary to the natural product fagaronine, which did not have any activity in the HSV1 antiviral tests, four 12-alkoxy derivatives showe...
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Veröffentlicht in: | Journal of enzyme inhibition and medicinal chemistry 2004-12, Vol.19 (6), p.481-487 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The synthesis of benzo[c]phenanthridine alkaloid derivatives is described. In vitro antiviral activity against herpes simplex type 1 (HSV1) has been investigated. Contrary to the natural product fagaronine, which did not have any activity in the HSV1 antiviral tests, four 12-alkoxy derivatives showed good activity demonstrating the importance of the 12-substitution in the structure-activity relationships. |
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ISSN: | 1475-6366 1475-6374 |
DOI: | 10.1080/14756360412331280518 |