Polypeptide from Chlamys farreri inhibits UVB-induced HaCaT cells apoptosis via inhibition CD95 pathway and reactive oxygen species

Polypeptide from Chlamys farreri (PCF) is a novel marine active product isolated from gonochoric Chinese scallop Chlamys farreri which has recently been found to be an effective antioxidant. In this study, we assessed the effect of PCF on UVB-induced intracellular signalling of apoptosis in HaCaT ce...

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Veröffentlicht in:	Free radical research 2007-11, Vol.41 (11), p.1224-1232
Hauptverfasser:	Li, Bing-Hua, Zhou, Ying-Bin, Guo, Shen-Bo, Wang, Chun-Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Animals apoptosis Apoptosis - drug effects Apoptosis - radiation effects CD95 Cells, Cultured Drug Evaluation, Preclinical fas Receptor - antagonists & inhibitors fas Receptor - genetics Fas-Associated Death Domain Protein - genetics Free Radical Scavengers - pharmacology Gene Expression - drug effects Gene Expression - radiation effects Humans Keratinocytes - drug effects Keratinocytes - metabolism Keratinocytes - physiology Keratinocytes - radiation effects Pectinidae - chemistry Peptides - isolation & purification Peptides - pharmacology Polypeptide from Chlamys farreri (PCF) reactive oxygen species (ROS) Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism RNA, Messenger - metabolism Signal Transduction - drug effects ultraviolet B (UVB) Ultraviolet Rays
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