Comparison of Bone Marrow Aspirates and Biopsies in Pediatric Patients with ALL at Days 7 and 14 of Induction Therapy

The percentage of blasts in the bone marrow aspirates at day 7 or 14 of induction therapy in pediatric ALL patients is an indicator of rapid early response and an independent prognostic factor for long term outcome. Discrepancies between the percentages of blasts in bone marrow aspirates compared to...

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Veröffentlicht in:	Leukemia & lymphoma 2004-04, Vol.45 (4), p.745-747
Hauptverfasser:	Countouriotis, Athena, Landaw, Elliot M, Naeim, Faramarz, Moore, Theodore B, Sakamoto, Kathleen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent ALL Biopsy Biopsy - standards Biopsy, Needle - standards Bone marrow aspiration Bone Marrow Examination - methods Child Child, Preschool Female Humans Induction Male Neoplasm, Residual - diagnosis Neoplasm, Residual - pathology Pediatric Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Prognosis Remission Induction Reproducibility of Results Retrospective Studies Time Factors Treatment Outcome
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Zusammenfassung:	The percentage of blasts in the bone marrow aspirates at day 7 or 14 of induction therapy in pediatric ALL patients is an indicator of rapid early response and an independent prognostic factor for long term outcome. Discrepancies between the percentages of blasts in bone marrow aspirates compared to biopsies have been reported. In a retrospective study on 44 consecutive patients diagnosed with ALL between 1998 and 2001, important differences were observed in the percentage of blasts between bone marrow aspirates and biopsies at days 7 and 14 of induction therapy.
ISSN:	1042-8194 1029-2403
DOI:	10.1080/10428190310001625863