Effect of γ-irradiation on Microtubule Assembly in Vitro

Effect of γ-irradiation on Microtubule Assembly in Vitro

Summary Microtubular protein was exposed to γ-radiation from 500 to 1000 Gy. Within that dose range its polymerization ability was decreased by 20-60 per cent when samples were irradiated in assembled state, and by 40-75 per cent when irradiated in unassembled state. Microtubules assembled from irra...

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Veröffentlicht in:International journal of radiation biology 1984, Vol.46 (4), p.435-442
Hauptverfasser: Gal, Vera, Trajkovi, Divna
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cattle
Gamma Rays
Microscopy, Electron
Microtubules - radiation effects
Microtubules - ultrastructure
Polymers
Protein Binding - radiation effects
Tubulin - metabolism
Tubulin - radiation effects
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Zusammenfassung:Summary Microtubular protein was exposed to γ-radiation from 500 to 1000 Gy. Within that dose range its polymerization ability was decreased by 20-60 per cent when samples were irradiated in assembled state, and by 40-75 per cent when irradiated in unassembled state. Microtubules assembled from irradiated subunits were shorter and of more uniform lengths than control microtubules. For the dose of 1000 Gy the mean length and its standard deviation were reduced to about one-half of the values of the control.
ISSN:0955-3002
0020-7616
1362-3095
DOI:10.1080/09553008414551631