Simultaneous ATP-AET-serotonin Protection of Spermatogonia from Mutations Induced by 300 R X-rays in the Mouse

Summary Protection of spermatogonia from dominant lethal mutations induced by acute whole-body X-irradiation (300 R) was studied in C57BL mice given a simultaneous injection of AET, ATP and serotonin. Evidence was obtained that simultaneous administration of these radioprotectors significantly reduc...

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Veröffentlicht in:	International journal of radiation biology 1974-01, Vol.26 (1), p.47-50
Hauptverfasser:	Benova, D.K., Baev, I.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - administration & dosage Adenosine Triphosphate - therapeutic use Animals beta-Aminoethyl Isothiourea - administration & dosage beta-Aminoethyl Isothiourea - therapeutic use Female Genes, Dominant Genes, Lethal Injections, Intraperitoneal Male Mice Mice, Inbred C57BL Mutation Radiation Genetics Radiation Injuries, Experimental - prevention & control Radiation-Protective Agents - administration & dosage Radiation-Protective Agents - therapeutic use Serotonin - administration & dosage Serotonin - therapeutic use Spermatozoa - drug effects Spermatozoa - radiation effects Translocation, Genetic
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Zusammenfassung:	Summary Protection of spermatogonia from dominant lethal mutations induced by acute whole-body X-irradiation (300 R) was studied in C57BL mice given a simultaneous injection of AET, ATP and serotonin. Evidence was obtained that simultaneous administration of these radioprotectors significantly reduced dominant lethality. Expected and observed rates of post-implantation loss were found to be of the same order of magnitude.
ISSN:	0955-3002 0020-7616 1362-3095
DOI:	10.1080/09553007414550931