Experiment and Discussion on Leukaemogenesis by Cell-free Extracts of Radiation-induced Leukaemia in Mice

Summary We have confirmed that cell-free extracts of radiation-induced leukaemia in C57 Bl mice contain an agent (virus) which produces lymphoid leukaemias when injected into isologous new-born or young adult non-irradiated mice. Therefore C57 Bl mice naturally harbour this virus and are not immune...

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Veröffentlicht in:	International journal of radiation biology 1962-01, Vol.5 (4), p.339-344
Hauptverfasser:	Latarjet, R., Duplan, J-F., Chamaillard, L., Monnot, P., Palaysi, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	ANIMAL CELLS Animals BIOLOGY AND MEDICINE CARCINOGENESIS IMMUNITY IRRADIATION LEUKEMIA Leukemia - transmission Leukemia, Radiation-Induced MICE Radiation Injuries, Experimental TISSUE EXTRACTS TISSUES VIRUSES
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Zusammenfassung:	Summary We have confirmed that cell-free extracts of radiation-induced leukaemia in C57 Bl mice contain an agent (virus) which produces lymphoid leukaemias when injected into isologous new-born or young adult non-irradiated mice. Therefore C57 Bl mice naturally harbour this virus and are not immune to it. This virus is inactive on AkR mice: it appears different from the Gross virus. From the discussion it is concluded that several processes cooperate in radio-leukaemogenesis. Some may concern the concentration of the virus; some others the competent cells of the host.
ISSN:	0955-3002 0020-7616 1362-3095
DOI:	10.1080/09553006214550911