Anticomplementary activity and complete 13C NMR assignment of citrostadienol from Schizandra chinensis

Abstract Citrostadienol was isolated from the fruits of Schizandra chinensis Baill: (Schizandraceae) by silica gel chromatography and assigned fully by spectroscopic analyses (1H-1H COSY: HMQC and HMBC). It demonstrated higher inhibition activity on classical complement pathway (IC50, 4.6 × 10−8M) t...

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Veröffentlicht in:	International journal of pharmacognosy 1997, Vol.35 (5), p.358-363
Hauptverfasser:	Lee, I.S, Oh, S.R, Jung, K.Y, Kim, D.S, Kim, J.H, Lee, H.K
Format:	Artikel
Sprache:	eng
Schlagworte:	anticomplementary activity anticomplementary properties bioassays Biological and medical sciences C NMR chemical constituents of plants chemical structure citrostadienol complement dosage fruits General pharmacology HMBC inhibition Medical sciences medicinal plants medicinal properties nuclear magnetic resonance spectroscopy Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytosterols Schisandra chinensis Schizandra chinensis Baill spectral analysis
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Beschreibung
Zusammenfassung:	Abstract Citrostadienol was isolated from the fruits of Schizandra chinensis Baill: (Schizandraceae) by silica gel chromatography and assigned fully by spectroscopic analyses (1H-1H COSY: HMQC and HMBC). It demonstrated higher inhibition activity on classical complement pathway (IC50, 4.6 × 10−8M) than previously reported active steroids.
ISSN:	0925-1618 1388-0209 1744-5116
DOI:	10.1080/09251619708951283