CHARACTERIZATION OF RESPIRATORY EXPOSURE TO AND EFFECTS OF COLD-AIR HYPERVENTILATION IN GUINEA PIGS

CHARACTERIZATION OF RESPIRATORY EXPOSURE TO AND EFFECTS OF COLD-AIR HYPERVENTILATION IN GUINEA PIGS

The purpose of this study was to characterize the respiratory effects of single and repeated controlled exposures to clean warm humid and cold dry air in a new model of anesthetized, mechanically ventilated guinea pigs, and to compare findings with known effects in humans. Intratracheal air (Ttr) an...

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Veröffentlicht in:Inhalation toxicology 2000-08, Vol.12 (8), p.649-669
Hauptverfasser: Halinen, Arja I, Pennanen, Arto S, Salonen, Raimo O
Format: Artikel
Sprache:eng
Schlagworte:
Adaptation, Physiological
Air
Animals
Bronchoconstriction - physiology
Cold Temperature
Guinea Pigs
Hemodynamics - drug effects
Humans
Hyperventilation - physiopathology
Inhalation Exposure
Male
Models, Animal
Propranolol - pharmacology
Pulmonary Ventilation - drug effects
Respiration, Artificial
Species Specificity
Tidal Volume - drug effects
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Zusammenfassung:The purpose of this study was to characterize the respiratory effects of single and repeated controlled exposures to clean warm humid and cold dry air in a new model of anesthetized, mechanically ventilated guinea pigs, and to compare findings with known effects in humans. Intratracheal air (Ttr) and retrotracheal tissue (Toe) temperatures and peak expiratory airflow (PEF), tidal volume (VT), heart rate, and blood pressure of hyperventilating animals were measured continuously. Four consecutive 10-min exposures to warm humid air (n = 7) produced slight airway warming and minimal lung function changes during the exposure. In a single 10-min exposure to cold dry air (n = 39), Ttr
ISSN:0895-8378
1091-7691
DOI:10.1080/08958370050085129