HEREDITARY MULTIPLE EXOSTOSES AND ACUTE MYELOID LEUKEMIA: An Unusual Association

Hereditary multiple exostoses (HME) is an autosomal dominant disorder characterized by the presence of multiple exostoses. Threegenetic loci have been identified, of which two (EXT1 and EXT2) have tumor suppressor activity. HME greatly increases the risk to develop sarcoma in the dysplastic tissue....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pediatric hematology and oncology 2000, Vol.17 (8), p.707-711
Hauptverfasser:	Gözda o lu, Sevgi, Uysal, Zümrüt, Kürekçi, A. Emin, Akarsu, Saadet, Ertem, Mehmet, Fitöz, Suat, kincio ullarí, Aydan, Cin, ükrü
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Biological and medical sciences Child Exostoses, Multiple Hereditary - complications Exostoses, Multiple Hereditary - diagnostic imaging Exostoses, Multiple Hereditary - genetics Female Hematologic and hematopoietic diseases Hereditary Humans Leukemia Leukemia, Myeloid - complications Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Multiple Exostoses Pedigree Radiography
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Hereditary multiple exostoses (HME) is an autosomal dominant disorder characterized by the presence of multiple exostoses. Threegenetic loci have been identified, of which two (EXT1 and EXT2) have tumor suppressor activity. HME greatly increases the risk to develop sarcoma in the dysplastic tissue. The authors report an 8-year-old girl with HME who developed acute myeloblastic leukemia.
ISSN:	0888-0018 1521-0669
DOI:	10.1080/08880010050211439