Regulatory T cells in peripheral blood of patients with mixed connective tissue disease

Regulatory T cells in peripheral blood of patients with mixed connective tissue disease

Objective: To determine the percentage and absolute number of CD4+ regulatory T-cells (Treg) in 48 patients with mixed connective tissue disease (MCTD). Methods: Data were classified on the basis of the stage of the disease: 17 patients were in the active stage and 31 in the inactive stage. The abso...

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Veröffentlicht in:Scandinavian journal of rheumatology 2006-07, Vol.35 (4), p.300-304
Hauptverfasser: Baráth, S., Sipka, S., Aleksza, M., Szegedi, A., Szodoray, P., Végh, J., Szegedi, G., Bodolay, E.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biological and medical sciences
Female
Humans
Interleukin-10 - metabolism
Male
Medical sciences
Middle Aged
Mixed Connective Tissue Disease - blood
Receptors, Interleukin-2 - metabolism
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
T-Lymphocytes, Regulatory - metabolism
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Zusammenfassung:Objective: To determine the percentage and absolute number of CD4+ regulatory T-cells (Treg) in 48 patients with mixed connective tissue disease (MCTD). Methods: Data were classified on the basis of the stage of the disease: 17 patients were in the active stage and 31 in the inactive stage. The absolute number of CD4+ intracellular interleukin-10+ (IL-10+) and CD4+CD25+high Treg cells was determined by flow cytometry. The percentage of CD4+CD25+high suppressor T-cells was determined on the basis of Foxp3 expression. Results: The percentage and the absolute number of CD4+CD25+high Treg cells were lower in patients than in healthy controls (p
ISSN:0300-9742
1502-7732
DOI:10.1080/03009740600709790