MRI patterns in prolonged low response states following traumatic brain injury in children and adolescents

Objectives: To explore the relationship between location and pattern of brain injury identified on MRI and prolonged low response state in children post-traumatic brain injury (TBI). Methods: This observational study compared 15 children who spontaneously recovered within 30 days post-TBI to 17 who...

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Veröffentlicht in:Brain injury 2007, Vol.21 (1), p.63-68
Hauptverfasser: Patrick, Peter D., Mabry, Jennifer L., Gurka, Matthew J., Buck, Marcia L., Boatwright, Evelyn, Blackman, James A.
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Sprache:eng
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Zusammenfassung:Objectives: To explore the relationship between location and pattern of brain injury identified on MRI and prolonged low response state in children post-traumatic brain injury (TBI). Methods: This observational study compared 15 children who spontaneously recovered within 30 days post-TBI to 17 who remained in a prolonged low response state. Results: 92.9% of children with brain stem injury were in the low response group. The predicted probability was 0.81 for brain stem injury alone, increasing to 0.95 with a regional pattern of injury to the brain stem, basal ganglia, and thalamus. Conclusions: Low response state in children post-TBI is strongly correlated with two distinctive regions of injury: the brain stem alone, and an injury pattern to the brain stem, basal ganglia, and thalamus. This study demonstrates the need for large-scale clinical studies using MRI as a tool for outcome assessment in children and adolescents following severe TBI.
ISSN:0269-9052
1362-301X
DOI:10.1080/02699050601111401