FERTILITY AFTER CHEMOTHERAPY FOR TESTICULAR CANCER
Disseminated testicular cancer has largely become curable with cisplatin-based chemotherapy. The prospect of fertility after treatment is an important consideration for both patients and clinicians. While there may be an irreversible impairment of spermatogenesis at a cumulative cisplatin dose of gr...
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| Veröffentlicht in: | Archives of andrology 2003-09, Vol.49 (5), p.389-395 |
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| container_end_page | 395 |
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| container_title | Archives of andrology |
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| creator | TAKSEY, J. BISSADA, N. K. CHAUDHARY, U. B. |
| description | Disseminated testicular cancer has largely become curable with cisplatin-based chemotherapy. The prospect of fertility after treatment is an important consideration for both patients and clinicians. While there may be an irreversible impairment of spermatogenesis at a cumulative cisplatin dose of greater than 400 mg/m 2, a low sperm count does not necessarily appear to prevent fatherhood. This review summarizes currently available data on the effects of chemotherapy on male fertility and steps that can be taken to preserve fertility in this patient population. |
| doi_str_mv | 10.1080/01485010390219917 |
| format | Article |
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This review summarizes currently available data on the effects of chemotherapy on male fertility and steps that can be taken to preserve fertility in this patient population.</description><identifier>ISSN: 0955-3002</identifier><identifier>ISSN: 0148-5016</identifier><identifier>EISSN: 1362-3095</identifier><identifier>EISSN: 1521-0375</identifier><identifier>DOI: 10.1080/01485010390219917</identifier><identifier>PMID: 12893517</identifier><identifier>CODEN: ARANDR</identifier><language>eng</language><publisher>Philadelphia, PA: Informa UK Ltd</publisher><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Chemotherapy ; Cisplatin - administration & dosage ; Cisplatin - adverse effects ; Fertility ; Fertility - drug effects ; Gynecology. Andrology. 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K.</creatorcontrib><creatorcontrib>CHAUDHARY, U. B.</creatorcontrib><title>FERTILITY AFTER CHEMOTHERAPY FOR TESTICULAR CANCER</title><title>Archives of andrology</title><addtitle>Arch Androl</addtitle><description>Disseminated testicular cancer has largely become curable with cisplatin-based chemotherapy. The prospect of fertility after treatment is an important consideration for both patients and clinicians. While there may be an irreversible impairment of spermatogenesis at a cumulative cisplatin dose of greater than 400 mg/m 2, a low sperm count does not necessarily appear to prevent fatherhood. This review summarizes currently available data on the effects of chemotherapy on male fertility and steps that can be taken to preserve fertility in this patient population.</description><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Cisplatin - administration & dosage</subject><subject>Cisplatin - adverse effects</subject><subject>Fertility</subject><subject>Fertility - drug effects</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Neoplasms, Germ Cell and Embryonal - drug therapy</subject><subject>Neoplasms, Germ Cell and Embryonal - physiopathology</subject><subject>Spermatogenesis - drug effects</subject><subject>Testicular Cancer</subject><subject>Testicular Neoplasms - drug therapy</subject><subject>Testicular Neoplasms - physiopathology</subject><subject>Tumors</subject><issn>0955-3002</issn><issn>0148-5016</issn><issn>1362-3095</issn><issn>1521-0375</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LwzAYh4Mobv75AF6kF4_VN02TJuillNYVqpPaHXYqaZuwjW4d6Ybs2xvZZIiwS_KD93nC-wtCdxgeMXB4AuxzChiIAA8LgYMzNMSEeS4BQc_R0J7UZvAG6KrvF2ATEH6JBtjjglAcDJGXxHmRZmkxdcKkiHMnGsVv42IU5-HH1EnGuVPEn0UaTbLQzsL3KM5v0IWWba9uD_c1miRxEY3cbPyaRmHm1j5jG1cRUdUVMAKMKe2zCnRQKxFIVtWBAEKJJsLXDQmE8CnIRgai0ZSCx1XQME6uEd6_W5uu743S5drMl9LsSgzlT__yX3_r3O-d9bZaquZoHApb4OEAyL6WrTZyVc_7I0eBM8KJ5V723HylO7OUX51pm3Ijd21nfiVyao_nP_pMyXYzq6VR5aLbmpX9txMtvgEaEYF6</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>TAKSEY, J.</creator><creator>BISSADA, N. 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B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-e39bcb063066ef46b0f7ce97a6bc790353f394fd3799450ada79df55028e7d683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Cisplatin - administration & dosage</topic><topic>Cisplatin - adverse effects</topic><topic>Fertility</topic><topic>Fertility - drug effects</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Neoplasms, Germ Cell and Embryonal - drug therapy</topic><topic>Neoplasms, Germ Cell and Embryonal - physiopathology</topic><topic>Spermatogenesis - drug effects</topic><topic>Testicular Cancer</topic><topic>Testicular Neoplasms - drug therapy</topic><topic>Testicular Neoplasms - physiopathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TAKSEY, J.</creatorcontrib><creatorcontrib>BISSADA, N. K.</creatorcontrib><creatorcontrib>CHAUDHARY, U. 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B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FERTILITY AFTER CHEMOTHERAPY FOR TESTICULAR CANCER</atitle><jtitle>Archives of andrology</jtitle><addtitle>Arch Androl</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>49</volume><issue>5</issue><spage>389</spage><epage>395</epage><pages>389-395</pages><issn>0955-3002</issn><issn>0148-5016</issn><eissn>1362-3095</eissn><eissn>1521-0375</eissn><coden>ARANDR</coden><abstract>Disseminated testicular cancer has largely become curable with cisplatin-based chemotherapy. The prospect of fertility after treatment is an important consideration for both patients and clinicians. While there may be an irreversible impairment of spermatogenesis at a cumulative cisplatin dose of greater than 400 mg/m 2, a low sperm count does not necessarily appear to prevent fatherhood. 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| fulltext | fulltext |
| identifier | ISSN: 0955-3002 |
| ispartof | Archives of andrology, 2003-09, Vol.49 (5), p.389-395 |
| issn | 0955-3002 0148-5016 1362-3095 1521-0375 |
| language | eng |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Chemotherapy Cisplatin - administration & dosage Cisplatin - adverse effects Fertility Fertility - drug effects Gynecology. Andrology. Obstetrics Humans Male Male genital diseases Medical sciences Neoplasms, Germ Cell and Embryonal - drug therapy Neoplasms, Germ Cell and Embryonal - physiopathology Spermatogenesis - drug effects Testicular Cancer Testicular Neoplasms - drug therapy Testicular Neoplasms - physiopathology Tumors |
| title | FERTILITY AFTER CHEMOTHERAPY FOR TESTICULAR CANCER |
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