FERTILITY AFTER CHEMOTHERAPY FOR TESTICULAR CANCER

Disseminated testicular cancer has largely become curable with cisplatin-based chemotherapy. The prospect of fertility after treatment is an important consideration for both patients and clinicians. While there may be an irreversible impairment of spermatogenesis at a cumulative cisplatin dose of gr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Archives of andrology 2003-09, Vol.49 (5), p.389-395
Hauptverfasser:	TAKSEY, J., BISSADA, N. K., CHAUDHARY, U. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Chemotherapy Cisplatin - administration & dosage Cisplatin - adverse effects Fertility Fertility - drug effects Gynecology. Andrology. Obstetrics Humans Male Male genital diseases Medical sciences Neoplasms, Germ Cell and Embryonal - drug therapy Neoplasms, Germ Cell and Embryonal - physiopathology Spermatogenesis - drug effects Testicular Cancer Testicular Neoplasms - drug therapy Testicular Neoplasms - physiopathology Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Disseminated testicular cancer has largely become curable with cisplatin-based chemotherapy. The prospect of fertility after treatment is an important consideration for both patients and clinicians. While there may be an irreversible impairment of spermatogenesis at a cumulative cisplatin dose of greater than 400 mg/m 2, a low sperm count does not necessarily appear to prevent fatherhood. This review summarizes currently available data on the effects of chemotherapy on male fertility and steps that can be taken to preserve fertility in this patient population.
ISSN:	0955-3002 0148-5016 1362-3095 1521-0375
DOI:	10.1080/01485010390219917