First detection of a VIM-1 metallo- -lactamase in a carbapenem-resistant Citrobacter freundii clinical isolate in an acute hospital in Germany

We report the first detection of a carbapenem-resistant Citrobacter freundii clinical strain in Germany. It was isolated from an abscess of a patient with acute necrotic pancreatitis in an acute hospital. PCR and sequencing experiments revealed that the carbapenem resistance was mediated by a VIM-1...

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Veröffentlicht in:Scandinavian journal of infectious diseases 2007, Vol.39 (3), p.264-266
Hauptverfasser: Weile, Jan, Rahmig, Harald, Gfröer, Sabine, Schroeppel, Klaus, Knabbe, Cornelius, Susa, Milorad
Format: Artikel
Sprache:eng
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Zusammenfassung:We report the first detection of a carbapenem-resistant Citrobacter freundii clinical strain in Germany. It was isolated from an abscess of a patient with acute necrotic pancreatitis in an acute hospital. PCR and sequencing experiments revealed that the carbapenem resistance was mediated by a VIM-1 metallo- -lactamase, located on a plasmid encoded class 1 integron. Carbapenem resistance in Enterobacteriaceae is so far a rare event and 1 of the major therapeutic concerns in the future.
ISSN:0036-5548
1651-1980
DOI:10.1080/00365540600868388