The Effect of Forskolin on the Sound-evoked Potentials in the Guinea Pig Cochlea

The effect of forskolin (FSK) on cochlear sound-evoked potentials was examined in the guinea pig. The perfusion of the scala vestibuli (SV) with FSK (2 &#50 10 -4 M) produced a significant increase in the amplitude of negative summating potential ( &#109 SP) with no change in cochlear microp...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta oto-laryngologica 1998, Vol.118 (533), p.4-8
1. Verfasser:	Kitano, Nozomu Mori, Kazuhiko Nario, Katsumi Doi, Takashi Matsunaga, Ikuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cochlea - drug effects Cochlea - physiology Cochlear Microphonic Potentials - drug effects Cochlear Microphonic Potentials - physiology Colforsin - pharmacology Endolymphatic Hydrops - etiology Guinea Pigs Ion Transport
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The effect of forskolin (FSK) on cochlear sound-evoked potentials was examined in the guinea pig. The perfusion of the scala vestibuli (SV) with FSK (2 &#50 10 -4 M) produced a significant increase in the amplitude of negative summating potential ( &#109 SP) with no change in cochlear microphonics (CM) amplitude, and a significant decrease in the amplitude of compound action potential (CAP) with a significant prolongation of N1 latency and a 20 dB CAP threshold elevation. The results lead us to speculate that FSK-induced changes may be involved in the transient formation of endolymphatic hydrops.
ISSN:	0001-6489 0365-5237 1651-2251
DOI:	10.1080/00016489850183647