Ultrasonic Backscatter Technique for Assessing and Monitoring Neonatal Cancellous Bone Status in Vivo

Ultrasonic Backscatter Technique for Assessing and Monitoring Neonatal Cancellous Bone Status in Vivo

Metabolic bone disease (MBD) impacts the prognosis of premature infants. There is an urgent need for a portable, noninvasive, and radiation-free method for assessing neonatal bone status. The objective of this study is to evaluate the feasibility of the ultrasonic backscatter technique for assessing...

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Veröffentlicht in:IEEE access 2019, Vol.7, p.157417-157426
Hauptverfasser: Mao, Weiying, Du, Yang, Liu, Chengcheng, Li, Boyi, Ta, Dean, Chen, Chao, Zhang, Rong
Format: Artikel
Sprache:eng
Schlagworte:
Acoustics
Age
Anthropometry
Backscatter
Backscattering
Bones
Cancellous bone
Correlation
Correlation analysis
Evaluation
Feasibility
Gestational age
In vivo methods and tests
Infants
Metabolic bone disease
Monitoring
Multiple births
neonate
Parameters
Pediatrics
Subgroups
Transducers
ultrasonic backscatter technique
Weight
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Zusammenfassung:Metabolic bone disease (MBD) impacts the prognosis of premature infants. There is an urgent need for a portable, noninvasive, and radiation-free method for assessing neonatal bone status. The objective of this study is to evaluate the feasibility of the ultrasonic backscatter technique for assessing and monitoring cancellous bone status in neonates. Ultrasonic backscatter measurements were performed on 766 infants at birth and followed up weekly during hospitalization, utilizing transducers with central frequencies of 3.5 MHz and 5.0 MHz. Backscatter parameters, including apparent integrated backscatter (AIB), frequency intercept of apparent backscatter (FIAB), and frequency slope of apparent backscatter (FSAB) were calculated. Correlations were analyzed with both anthropometric and biochemical indices. We found that AIB (|r| = 0.40-0.47, p
ISSN:2169-3536
2169-3536
DOI:10.1109/ACCESS.2019.2949748