SICOR: Subgraph Isomorphism Comparison of RNA Secondary Structures

SICOR: Subgraph Isomorphism Comparison of RNA Secondary Structures

RNA aptamer selection during SELEX experiments builds on secondary structural diversity. Advanced structural comparison methods can focus this diversity. We develop SICOR , which uses probabilistic subgraph isomorphisms for graph distances between RNA secondary structure graphs. SICOR outperforms ot...

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Veröffentlicht in:IEEE/ACM transactions on computational biology and bioinformatics 2020-11, Vol.17 (6), p.2189-2195
Hauptverfasser: Schmidt, Michael, Hamacher, Kay, Reinhardt, Felix, Lotz, Thea S., Groher, Florian, Suess, Beatrix, Jager, Sven
Format: Artikel
Sprache:eng
Schlagworte:
Aptamers
Design of experiments
Experimental design
Forestry
Graph theory
Isomorphism
Measurement
Probabilistic logic
Protein structure
Protocols
Ribonucleic acid
RNA
RNA structure comparison
Secondary structure
SELEX
subgraph isomorphism
Transmission line matrix methods
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Beschreibung
Zusammenfassung:RNA aptamer selection during SELEX experiments builds on secondary structural diversity. Advanced structural comparison methods can focus this diversity. We develop SICOR , which uses probabilistic subgraph isomorphisms for graph distances between RNA secondary structure graphs. SICOR outperforms other comparison methods and is applicable to many structural comparisons in experimental design.
ISSN:1545-5963
1557-9964
DOI:10.1109/TCBB.2019.2926711