Study on the Effects of Magnetic Stimulation on K-Ras-Driven Lung Cancer in Mice

Mutations in the K-Ras gene are more common in primary lung adenocarcinoma than others. The effects of chemotherapy and radiation therapy to K-Ras mutation lung cancer are not ideal. In the past decades, the electromagnetic stimulation on biological tissue received more attention. Magnetic stimulation suggested a new method for tumor treatment. In this paper, based on the A549 lung tumor cell experiment that was carried out in our previous study, a pair of stimulation coil was developed to apply the magnetic field on lung cancer cells in mice. The distribution of the magnetic field applied to K-Ras-driven lung cancer cells is simulated. By appropriate design, the magnetic flux density of target cells was up to 2.0 mT. The biological experiments are conducted. After 2 weeks, the biological experiments showed that magnetic field stimulation could suppress the growth of K-Ras-driven lung cancer.