Evaluating exponential integrators for Markov chain ion channel models

Evaluating exponential integrators for Markov chain ion channel models

We evaluate the accuracy and efficiency of an exponential integrator method applied to a cardiac excitation model with numerically stiff Markov chain (MC) description of ionic channels, namely Ryanodine receptor (RyR) and L-type calcium channel ICa(L). If solved by explicit methods such as forward E...

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Hauptverfasser: Stary, Tomas, Biktashev, Vadim N.
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Calcium
Cardiology
Channels
Computation
Computational modeling
Conferences
Integrators
Ion channels
Iron
Logic gates
Markov chains
Markov processes
Mathematical model
Mathematical models
Numerical models
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Beschreibung
Zusammenfassung:We evaluate the accuracy and efficiency of an exponential integrator method applied to a cardiac excitation model with numerically stiff Markov chain (MC) description of ionic channels, namely Ryanodine receptor (RyR) and L-type calcium channel ICa(L). If solved by explicit methods such as forward Euler (FE), the stability constraints for these MC models require very small time steps.
ISSN:2325-8861
2325-887X
DOI:10.1109/CIC.2015.7411053