Pudendal neuromodulation with a closed-loop control strategy to improve bladder functions in the animal study
The aim of this study was to develop a new closed-loop control strategy for improving bladder emptying and verify its performance in animal experiments. Two channel outputs of electrical currents triggered by intravesical pressure (IVP)-feedback signals were set to automatically regulate the rat...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Format: | Tagungsbericht |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3629 |
|---|---|
| container_issue | |
| container_start_page | 3626 |
| container_title | |
| container_volume | 2013 |
| creator | Peng, Chih-Wei Lin, Yin-Tsong Chen, Shih-Ching Kuo, Te-Son |
| description | The aim of this study was to develop a new closed-loop control strategy for improving bladder emptying and verify its performance in animal experiments. Two channel outputs of electrical currents triggered by intravesical pressure (IVP)-feedback signals were set to automatically regulate the rat's pudendal nerve for selective nerve stimulation and blocking. Under this experimental design, a series of in-vivo animal experiments were conducted on anesthetized rats. Our results showed that the IVP-feedback control strategy for dual-channel pudendal neuromodulation performed well in animal experiments and could be utilized to selectively stimulate and block the pudendal nerve to augment bladder contraction and restore external urethral sphincter (EUS) bursting activity to simultaneously improve bladder emptying. This study demonstrates the feasibility of the IVP-based feedback-control strategy with animal experiments, and the results could provide a basis for developing a sophisticated neural prosthesis for restoring bladder function in clinical use or the relative neurophysiological study. |
| doi_str_mv | 10.1109/EMBC.2013.6610328 |
| format | Conference Proceeding |
| fullrecord | <record><control><sourceid>pubmed_6IE</sourceid><recordid>TN_cdi_ieee_primary_6610328</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ieee_id>6610328</ieee_id><sourcerecordid>24110515</sourcerecordid><originalsourceid>FETCH-LOGICAL-i301t-d355bd8806dd64ff6411d05869a274a21a0c9a11b1291d0d6a7d6f38c7cc314d3</originalsourceid><addsrcrecordid>eNo9UMtKw0AUHUWxtfYDRJD5gdS588pkqaE-oKILBXdlkjuxkSQTkonSvzel1dU5cB6cewm5BLYAYMnN8vkuXXAGYqE1MMHNETkHqeKYcdDJMZmCUiaSGtTJyFkiI23ijwmZ9_0XYwxirQUXZ2TC5dinQE1J_Tqga9BWtHFD52uPQ2VD6Rv6U4YNtTSvfO8wqrxvae6b0PmK9qGzwX1uafC0rNvOfzuaVRbRdbQYmnyX72nZ0LBx1DZlbXeZAbcX5LSwVe_mB5yR9_vlW_oYrV4entLbVVQKBiFCoVSGxjCNqGVR6HEuMmV0YnksLQfL8sQCZMCTUUBtY9SFMHmc5wIkihm53ve2Q1Y7XLfduKHbrv_uHg1Xe0PpnPuXD18Vv8l7aC4</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>conference_proceeding</recordtype></control><display><type>conference_proceeding</type><title>Pudendal neuromodulation with a closed-loop control strategy to improve bladder functions in the animal study</title><source>IEEE Electronic Library (IEL) Conference Proceedings</source><creator>Peng, Chih-Wei ; Lin, Yin-Tsong ; Chen, Shih-Ching ; Kuo, Te-Son</creator><creatorcontrib>Peng, Chih-Wei ; Lin, Yin-Tsong ; Chen, Shih-Ching ; Kuo, Te-Son</creatorcontrib><description>The aim of this study was to develop a new closed-loop control strategy for improving bladder emptying and verify its performance in animal experiments. Two channel outputs of electrical currents triggered by intravesical pressure (IVP)-feedback signals were set to automatically regulate the rat's pudendal nerve for selective nerve stimulation and blocking. Under this experimental design, a series of in-vivo animal experiments were conducted on anesthetized rats. Our results showed that the IVP-feedback control strategy for dual-channel pudendal neuromodulation performed well in animal experiments and could be utilized to selectively stimulate and block the pudendal nerve to augment bladder contraction and restore external urethral sphincter (EUS) bursting activity to simultaneously improve bladder emptying. This study demonstrates the feasibility of the IVP-based feedback-control strategy with animal experiments, and the results could provide a basis for developing a sophisticated neural prosthesis for restoring bladder function in clinical use or the relative neurophysiological study.</description><identifier>ISSN: 1094-687X</identifier><identifier>ISSN: 1557-170X</identifier><identifier>EISSN: 1558-4615</identifier><identifier>EISBN: 1457702169</identifier><identifier>EISBN: 9781457702167</identifier><identifier>DOI: 10.1109/EMBC.2013.6610328</identifier><identifier>PMID: 24110515</identifier><language>eng</language><publisher>United States: IEEE</publisher><subject>Animals ; Bladder ; Educational institutions ; Electrodes ; Electromyography ; Female ; Humans ; Neural Prostheses ; Prosthesis Design ; Pudendal Nerve - physiology ; Rats ; Rats, Sprague-Dawley ; Recovery of Function ; Surgery ; Timing ; Urethra - innervation ; Urethra - physiology ; Urinary Bladder - innervation ; Urinary Bladder - physiology</subject><ispartof>2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2013, Vol.2013, p.3626-3629</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/6610328$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>309,310,780,784,789,790,2058,27925,54920</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/6610328$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24110515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, Chih-Wei</creatorcontrib><creatorcontrib>Lin, Yin-Tsong</creatorcontrib><creatorcontrib>Chen, Shih-Ching</creatorcontrib><creatorcontrib>Kuo, Te-Son</creatorcontrib><title>Pudendal neuromodulation with a closed-loop control strategy to improve bladder functions in the animal study</title><title>2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)</title><addtitle>EMBC</addtitle><addtitle>Conf Proc IEEE Eng Med Biol Soc</addtitle><description>The aim of this study was to develop a new closed-loop control strategy for improving bladder emptying and verify its performance in animal experiments. Two channel outputs of electrical currents triggered by intravesical pressure (IVP)-feedback signals were set to automatically regulate the rat's pudendal nerve for selective nerve stimulation and blocking. Under this experimental design, a series of in-vivo animal experiments were conducted on anesthetized rats. Our results showed that the IVP-feedback control strategy for dual-channel pudendal neuromodulation performed well in animal experiments and could be utilized to selectively stimulate and block the pudendal nerve to augment bladder contraction and restore external urethral sphincter (EUS) bursting activity to simultaneously improve bladder emptying. This study demonstrates the feasibility of the IVP-based feedback-control strategy with animal experiments, and the results could provide a basis for developing a sophisticated neural prosthesis for restoring bladder function in clinical use or the relative neurophysiological study.</description><subject>Animals</subject><subject>Bladder</subject><subject>Educational institutions</subject><subject>Electrodes</subject><subject>Electromyography</subject><subject>Female</subject><subject>Humans</subject><subject>Neural Prostheses</subject><subject>Prosthesis Design</subject><subject>Pudendal Nerve - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recovery of Function</subject><subject>Surgery</subject><subject>Timing</subject><subject>Urethra - innervation</subject><subject>Urethra - physiology</subject><subject>Urinary Bladder - innervation</subject><subject>Urinary Bladder - physiology</subject><issn>1094-687X</issn><issn>1557-170X</issn><issn>1558-4615</issn><isbn>1457702169</isbn><isbn>9781457702167</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2013</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><sourceid>EIF</sourceid><recordid>eNo9UMtKw0AUHUWxtfYDRJD5gdS588pkqaE-oKILBXdlkjuxkSQTkonSvzel1dU5cB6cewm5BLYAYMnN8vkuXXAGYqE1MMHNETkHqeKYcdDJMZmCUiaSGtTJyFkiI23ijwmZ9_0XYwxirQUXZ2TC5dinQE1J_Tqga9BWtHFD52uPQ2VD6Rv6U4YNtTSvfO8wqrxvae6b0PmK9qGzwX1uafC0rNvOfzuaVRbRdbQYmnyX72nZ0LBx1DZlbXeZAbcX5LSwVe_mB5yR9_vlW_oYrV4entLbVVQKBiFCoVSGxjCNqGVR6HEuMmV0YnksLQfL8sQCZMCTUUBtY9SFMHmc5wIkihm53ve2Q1Y7XLfduKHbrv_uHg1Xe0PpnPuXD18Vv8l7aC4</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Peng, Chih-Wei</creator><creator>Lin, Yin-Tsong</creator><creator>Chen, Shih-Ching</creator><creator>Kuo, Te-Son</creator><general>IEEE</general><scope>6IE</scope><scope>6IH</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIO</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20130101</creationdate><title>Pudendal neuromodulation with a closed-loop control strategy to improve bladder functions in the animal study</title><author>Peng, Chih-Wei ; Lin, Yin-Tsong ; Chen, Shih-Ching ; Kuo, Te-Son</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i301t-d355bd8806dd64ff6411d05869a274a21a0c9a11b1291d0d6a7d6f38c7cc314d3</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Bladder</topic><topic>Educational institutions</topic><topic>Electrodes</topic><topic>Electromyography</topic><topic>Female</topic><topic>Humans</topic><topic>Neural Prostheses</topic><topic>Prosthesis Design</topic><topic>Pudendal Nerve - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Recovery of Function</topic><topic>Surgery</topic><topic>Timing</topic><topic>Urethra - innervation</topic><topic>Urethra - physiology</topic><topic>Urinary Bladder - innervation</topic><topic>Urinary Bladder - physiology</topic><toplevel>online_resources</toplevel><creatorcontrib>Peng, Chih-Wei</creatorcontrib><creatorcontrib>Lin, Yin-Tsong</creatorcontrib><creatorcontrib>Chen, Shih-Ching</creatorcontrib><creatorcontrib>Kuo, Te-Son</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan (POP) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Electronic Library (IEL)</collection><collection>IEEE Proceedings Order Plans (POP) 1998-present</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Peng, Chih-Wei</au><au>Lin, Yin-Tsong</au><au>Chen, Shih-Ching</au><au>Kuo, Te-Son</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Pudendal neuromodulation with a closed-loop control strategy to improve bladder functions in the animal study</atitle><btitle>2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)</btitle><stitle>EMBC</stitle><addtitle>Conf Proc IEEE Eng Med Biol Soc</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>2013</volume><spage>3626</spage><epage>3629</epage><pages>3626-3629</pages><issn>1094-687X</issn><issn>1557-170X</issn><eissn>1558-4615</eissn><eisbn>1457702169</eisbn><eisbn>9781457702167</eisbn><abstract>The aim of this study was to develop a new closed-loop control strategy for improving bladder emptying and verify its performance in animal experiments. Two channel outputs of electrical currents triggered by intravesical pressure (IVP)-feedback signals were set to automatically regulate the rat's pudendal nerve for selective nerve stimulation and blocking. Under this experimental design, a series of in-vivo animal experiments were conducted on anesthetized rats. Our results showed that the IVP-feedback control strategy for dual-channel pudendal neuromodulation performed well in animal experiments and could be utilized to selectively stimulate and block the pudendal nerve to augment bladder contraction and restore external urethral sphincter (EUS) bursting activity to simultaneously improve bladder emptying. This study demonstrates the feasibility of the IVP-based feedback-control strategy with animal experiments, and the results could provide a basis for developing a sophisticated neural prosthesis for restoring bladder function in clinical use or the relative neurophysiological study.</abstract><cop>United States</cop><pub>IEEE</pub><pmid>24110515</pmid><doi>10.1109/EMBC.2013.6610328</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 1094-687X |
| ispartof | 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2013, Vol.2013, p.3626-3629 |
| issn | 1094-687X 1557-170X 1558-4615 |
| language | eng |
| recordid | cdi_ieee_primary_6610328 |
| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Animals Bladder Educational institutions Electrodes Electromyography Female Humans Neural Prostheses Prosthesis Design Pudendal Nerve - physiology Rats Rats, Sprague-Dawley Recovery of Function Surgery Timing Urethra - innervation Urethra - physiology Urinary Bladder - innervation Urinary Bladder - physiology |
| title | Pudendal neuromodulation with a closed-loop control strategy to improve bladder functions in the animal study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T13%3A59%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_6IE&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=proceeding&rft.atitle=Pudendal%20neuromodulation%20with%20a%20closed-loop%20control%20strategy%20to%20improve%20bladder%20functions%20in%20the%20animal%20study&rft.btitle=2013%2035th%20Annual%20International%20Conference%20of%20the%20IEEE%20Engineering%20in%20Medicine%20and%20Biology%20Society%20(EMBC)&rft.au=Peng,%20Chih-Wei&rft.date=2013-01-01&rft.volume=2013&rft.spage=3626&rft.epage=3629&rft.pages=3626-3629&rft.issn=1094-687X&rft.eissn=1558-4615&rft_id=info:doi/10.1109/EMBC.2013.6610328&rft_dat=%3Cpubmed_6IE%3E24110515%3C/pubmed_6IE%3E%3Curl%3E%3C/url%3E&rft.eisbn=1457702169&rft.eisbn_list=9781457702167&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/24110515&rft_ieee_id=6610328&rfr_iscdi=true |