Simulation of digoxin single molecule detection through resonant frequency shift of a CNT

In this paper, the possibility of using natural resonant frequency shift of a Carbon Nanotube (CNT) as a bio sensor has been studied. The frequency shift of a CNT cantilever beam oscillator due to the placement of a single Digoxin bio molecule has been studied. Digoxin is widely used as a cardiac glycoside drug in the treatment of various heart conditions. Since, it is a toxic drug, it should be regularly monitored in the serum of patients under treatment. In this study the effect of changing diameter and length of the CNT cantilever beam has been analyzed. Frequency shifts has been analyzed by continuum mechanics and CNT has been equalized by a shell. Required processes have been done using Finite Element Method (FEM). Simulation shows that decreasing the length and radius of the CNT caused the sensitivity to increase.