Tracking Genes Modifications in the Pedigree through GeneTracer Algorithm

Genes acquire many changes and modifications during evolution producing many orthologous and paralogous. One of the main challenges for biologist is tracing back the origin of modified genes in the genomes of various organisms. Tracing genes modifications and developments from the ancestors to offsp...

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Hauptverfasser: Issa, M., Bakr, H. M. A., Alzohairy, A. M., Ziedan, I. E.
Format: Tagungsbericht
Sprache:eng
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Zusammenfassung:Genes acquire many changes and modifications during evolution producing many orthologous and paralogous. One of the main challenges for biologist is tracing back the origin of modified genes in the genomes of various organisms. Tracing genes modifications and developments from the ancestors to offsprings is however a massive task for biologists. Thus, computer programs can help biologists tracking down those changes through sequence alignment. In this paper, we present an algorithm, called GeneTracer and based on sequence alignment, that, given two ancestor sequences and their offspring one, tracks down genes modification in the ancestor sequences and finds related parts of each ancestor in the offspring one.
ISSN:1529-4188
2378-3915
DOI:10.1109/DEXA.2012.20