TGF-Beta and CTGF Mediated Signal Transduction Pathway and Fibrosis

TGF-Beta and CTGF Mediated Signal Transduction Pathway and Fibrosis

Transforming growth factor-beta (TGF-β) is one of the important cell factors which cause the fibrous function, and connective tissue growth factor (CTGF) is considered to be the downstream factor of TGF-β, mediates fibrosis of TGF-β. TGF-β induces the expression of CTGF through multiple signal trans...

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Bibliographische Detailangaben
Hauptverfasser: Jingrui Tian, Fang Yang, Huiqin Liu
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Connective tissue
CTGF
Electronic countermeasures
Fibroblasts
fibrosis
Humans
Lungs
Proteins
signal transduction
TGF-?
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Beschreibung
Zusammenfassung:Transforming growth factor-beta (TGF-β) is one of the important cell factors which cause the fibrous function, and connective tissue growth factor (CTGF) is considered to be the downstream factor of TGF-β, mediates fibrosis of TGF-β. TGF-β induces the expression of CTGF through multiple signal transduction pathways in promoting fibrosis. This article provides a brief summary of the research progress in this area.
DOI:10.1109/iCBEB.2012.397