A software package for next-gen bisulfite sequencing data analysis

A software package for next-gen bisulfite sequencing data analysis

Bisulfite sequencing (BS-seq) is one of the most important sequencing protocols for genome-wide DNA methylation studies. However, it causes significant challenges in computation because it converts unmethylated cytosines to thymines. This paper presents a software package to address those challenges...

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Bibliographische Detailangaben
Hauptverfasser: Jeong-Hyeon Choi, Dong-Sung Ryu, Sureshchandra, S., Huidong Shi, Hwan-Gue Cho
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Bioinformatics
bisulfite sequencing
Computational efficiency
Diseases
DNA
DNA methylation
Genomics
next-gen sequencing
Pipelines
Software packages
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Beschreibung
Zusammenfassung:Bisulfite sequencing (BS-seq) is one of the most important sequencing protocols for genome-wide DNA methylation studies. However, it causes significant challenges in computation because it converts unmethylated cytosines to thymines. This paper presents a software package to address those challenges and to provide various kinds of analysis modules, from mapping to comparing multiple samples.
DOI:10.1109/BIBMW.2011.6112561