Dual-molecule spectroscopy: molecular rulers for the study of biological macromolecules

Dual-molecule spectroscopy: molecular rulers for the study of biological macromolecules

Single-molecule detection and spectroscopy by laser induced fluorescence offer many applications to life sciences. We review recent techniques and experiments based on the detection and spectroscopy of two near-by molecules. The spectroscopic signature of the light emitted from the two molecules can...

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Veröffentlicht in:IEEE journal of selected topics in quantum electronics 1996-12, Vol.2 (4), p.1115-1128
Hauptverfasser: Ha, T., Enderle, Th, Chemla, D.S., Weiss, S.
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical optical imaging
Chemical lasers
Fluorescence
Laser excitation
Laser theory
Molecular biophysics
Optical microscopy
Probes
Spectroscopy
Surface emitting lasers
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Beschreibung
Zusammenfassung:Single-molecule detection and spectroscopy by laser induced fluorescence offer many applications to life sciences. We review recent techniques and experiments based on the detection and spectroscopy of two near-by molecules. The spectroscopic signature of the light emitted from the two molecules can be used to measure the distance, orientation and relative dynamics between biological macromolecules.
ISSN:1077-260X
1558-4542
DOI:10.1109/2944.577342