Evaluation of model-independent deconvolution techniques to estimate blood perfusion

This report evaluates several methods to estimate blood perfusion and residue functions in dynamic contrast enhanced (DCE) MRI. Among these are model-dependent and model-independent techniques. All methods were applied to series of Monte Carlo simulations to evaluate the accuracy in order to reprodu...

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Veröffentlicht in:2010 Annual International Conference of the IEEE Engineering in Medicine and Biology 2010-01, Vol.2010, p.2602-2607
Hauptverfasser: Kind, Taco, Houtzager, Ivo, Faes, Theo J C, Hofman, Mark B M
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Sprache:eng
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Zusammenfassung:This report evaluates several methods to estimate blood perfusion and residue functions in dynamic contrast enhanced (DCE) MRI. Among these are model-dependent and model-independent techniques. All methods were applied to series of Monte Carlo simulations to evaluate the accuracy in order to reproduce different underlying vascular residue functions and blood perfusions. Of the model-independent approaches the use of B-splines with Tikhonov regularization was shown to have a reasonable accuracy in blood perfusion estimations and was less biased than all model-dependent approaches. This technique seems most promising for application to experimental data.
ISSN:1094-687X
1557-170X
1558-4615
DOI:10.1109/IEMBS.2010.5626615