Non-invasive fetal therapy using histotripsy: Feasibility study in the sheep model
Pulsed cavitational ultrasound, or histotripsy, has been shown to be an effective technique to mechanically fractionate tissue through controlled cavitation. In this study, we investigate the feasibility of using histotripsy as a therapeutic tool to non-invasively fractionate and remove fetal tissue...
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| creator | Yohan Kim Fifer, C.G. Gelehrter, S.K. Williams, J. Lu, J.C. Cain, C.A. Zhen Xu |
| description | Pulsed cavitational ultrasound, or histotripsy, has been shown to be an effective technique to mechanically fractionate tissue through controlled cavitation. In this study, we investigate the feasibility of using histotripsy as a therapeutic tool to non-invasively fractionate and remove fetal tissue. Pregnant ewes at 102-129 days into gestation were exposed to histotripsy by a focused 1 MHz transducer coupled to the maternal abdominal wall. The fetal heart, kidney and liver were exposed to short ultrasound pulses ( |
| doi_str_mv | 10.1109/ULTSYM.2009.5442016 |
| format | Conference Proceeding |
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In this study, we investigate the feasibility of using histotripsy as a therapeutic tool to non-invasively fractionate and remove fetal tissue. Pregnant ewes at 102-129 days into gestation were exposed to histotripsy by a focused 1 MHz transducer coupled to the maternal abdominal wall. The fetal heart, kidney and liver were exposed to short ultrasound pulses (<10 ¿s) at a 1 kHz pulse repetition rate and 10-16 MPa peak negative pressure. The entire procedure was guided and monitored by real-time ultrasound imaging. A total of 11 experiments were performed and preliminary results show that with suitable acoustic windows, histotripsy was able to generate a cavitation bubble cloud at the targeted fetal tissue and create mechanical tissue fractionation and removal. Morphological and histological assessment of the treated tissue confirmed that lesion locations corresponded to regions where the cavitation bubble cloud was observed. 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These results suggest that histotripsy has potential to become a non-invasive clinical tool for early fetal intervention on congenital anomalies such as prenatal treatment for hypoplastic left heart syndrome.</description><subject>Abdomen</subject><subject>Acoustic pulses</subject><subject>cavitation</subject><subject>Clouds</subject><subject>Fetal heart</subject><subject>fetal surgery</subject><subject>Focusing</subject><subject>Fractionation</subject><subject>histotripsy</subject><subject>Medical treatment</subject><subject>Pregnancy</subject><subject>therapeutic ultrasound</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonic transducers</subject><issn>1051-0117</issn><isbn>142444389X</isbn><isbn>9781424443895</isbn><isbn>9781424443901</isbn><isbn>1424443903</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2009</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><recordid>eNotkNFKwzAUhiMq6OaeYDd5gc5z0iRNvJPhVJgKOkGvRtKeukjXlSYb9O1V3NXHDx__xcfYFGGGCPb6fbl6-3yaCQA7U1IKQH3CJrYwKIWUMreAp2x0HMZ-nLFLBIUZIBYXbBTjN4AAJeQle33etVloDy6GA_Gakmt42lDvuoHvY2i_-CbEtEt96OJwwxf0K_rQhDTwmPbVwEP75_O4Ier4dldRc8XOa9dEmhw5ZqvF3Wr-kC1f7h_nt8ssWEgZao-m9KCNLQRWWktw0utcmUIbp0xFjmStKmtdXgAoL8rSy9oVpTNY5T4fs-n_bSCiddeHreuH9TFH_gOO0VNL</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>Yohan Kim</creator><creator>Fifer, C.G.</creator><creator>Gelehrter, S.K.</creator><creator>Williams, J.</creator><creator>Lu, J.C.</creator><creator>Cain, C.A.</creator><creator>Zhen Xu</creator><general>IEEE</general><scope>6IE</scope><scope>6IH</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIO</scope></search><sort><creationdate>200909</creationdate><title>Non-invasive fetal therapy using histotripsy: Feasibility study in the sheep model</title><author>Yohan Kim ; Fifer, C.G. ; Gelehrter, S.K. ; Williams, J. ; Lu, J.C. ; Cain, C.A. ; Zhen Xu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i90t-16b18cb0689721d6640a4b6358768a58deae4f5d99a37005b2ccb4fa7ca81d3b3</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Abdomen</topic><topic>Acoustic pulses</topic><topic>cavitation</topic><topic>Clouds</topic><topic>Fetal heart</topic><topic>fetal surgery</topic><topic>Focusing</topic><topic>Fractionation</topic><topic>histotripsy</topic><topic>Medical treatment</topic><topic>Pregnancy</topic><topic>therapeutic ultrasound</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonic transducers</topic><toplevel>online_resources</toplevel><creatorcontrib>Yohan Kim</creatorcontrib><creatorcontrib>Fifer, C.G.</creatorcontrib><creatorcontrib>Gelehrter, S.K.</creatorcontrib><creatorcontrib>Williams, J.</creatorcontrib><creatorcontrib>Lu, J.C.</creatorcontrib><creatorcontrib>Cain, C.A.</creatorcontrib><creatorcontrib>Zhen Xu</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan (POP) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Electronic Library (IEL)</collection><collection>IEEE Proceedings Order Plans (POP) 1998-present</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Yohan Kim</au><au>Fifer, C.G.</au><au>Gelehrter, S.K.</au><au>Williams, J.</au><au>Lu, J.C.</au><au>Cain, C.A.</au><au>Zhen Xu</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Non-invasive fetal therapy using histotripsy: Feasibility study in the sheep model</atitle><btitle>2009 IEEE International Ultrasonics Symposium</btitle><stitle>ULTSYM</stitle><date>2009-09</date><risdate>2009</risdate><spage>228</spage><epage>231</epage><pages>228-231</pages><issn>1051-0117</issn><isbn>142444389X</isbn><isbn>9781424443895</isbn><eisbn>9781424443901</eisbn><eisbn>1424443903</eisbn><abstract>Pulsed cavitational ultrasound, or histotripsy, has been shown to be an effective technique to mechanically fractionate tissue through controlled cavitation. In this study, we investigate the feasibility of using histotripsy as a therapeutic tool to non-invasively fractionate and remove fetal tissue. Pregnant ewes at 102-129 days into gestation were exposed to histotripsy by a focused 1 MHz transducer coupled to the maternal abdominal wall. The fetal heart, kidney and liver were exposed to short ultrasound pulses (<10 ¿s) at a 1 kHz pulse repetition rate and 10-16 MPa peak negative pressure. The entire procedure was guided and monitored by real-time ultrasound imaging. A total of 11 experiments were performed and preliminary results show that with suitable acoustic windows, histotripsy was able to generate a cavitation bubble cloud at the targeted fetal tissue and create mechanical tissue fractionation and removal. Morphological and histological assessment of the treated tissue confirmed that lesion locations corresponded to regions where the cavitation bubble cloud was observed. These results suggest that histotripsy has potential to become a non-invasive clinical tool for early fetal intervention on congenital anomalies such as prenatal treatment for hypoplastic left heart syndrome.</abstract><pub>IEEE</pub><doi>10.1109/ULTSYM.2009.5442016</doi><tpages>4</tpages></addata></record> |
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| ispartof | 2009 IEEE International Ultrasonics Symposium, 2009, p.228-231 |
| issn | 1051-0117 |
| language | eng |
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| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Abdomen Acoustic pulses cavitation Clouds Fetal heart fetal surgery Focusing Fractionation histotripsy Medical treatment Pregnancy therapeutic ultrasound Ultrasonic imaging Ultrasonic transducers |
| title | Non-invasive fetal therapy using histotripsy: Feasibility study in the sheep model |
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