Non-invasive fetal therapy using histotripsy: Feasibility study in the sheep model

Non-invasive fetal therapy using histotripsy: Feasibility study in the sheep model

Pulsed cavitational ultrasound, or histotripsy, has been shown to be an effective technique to mechanically fractionate tissue through controlled cavitation. In this study, we investigate the feasibility of using histotripsy as a therapeutic tool to non-invasively fractionate and remove fetal tissue...

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Bibliographische Detailangaben
Hauptverfasser: Yohan Kim, Fifer, C.G., Gelehrter, S.K., Williams, J., Lu, J.C., Cain, C.A., Zhen Xu
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Abdomen
Acoustic pulses
cavitation
Clouds
Fetal heart
fetal surgery
Focusing
Fractionation
histotripsy
Medical treatment
Pregnancy
therapeutic ultrasound
Ultrasonic imaging
Ultrasonic transducers
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Beschreibung
Zusammenfassung:Pulsed cavitational ultrasound, or histotripsy, has been shown to be an effective technique to mechanically fractionate tissue through controlled cavitation. In this study, we investigate the feasibility of using histotripsy as a therapeutic tool to non-invasively fractionate and remove fetal tissue. Pregnant ewes at 102-129 days into gestation were exposed to histotripsy by a focused 1 MHz transducer coupled to the maternal abdominal wall. The fetal heart, kidney and liver were exposed to short ultrasound pulses (
ISSN:1051-0117
DOI:10.1109/ULTSYM.2009.5442016