Polyacrylic acid-derivatized superparamagnetic iron oxide nanoparticles for delivery of tissue plasminogen activator

Polyacrylic acid-derivatized superparamagnetic iron oxide nanoparticles for delivery of tissue plasminogen activator

Polyacrylic acid (PAA)-derivatized Fe 3 O 4 magnetic nanoparticle (MNP) intended as a drug carrier were synthesized by two different approaches and studied for chemicophysical properties. PAA-MNP prepared by physical adsorption of PAA on pre-formed MNP showed better properties for covalent binding w...

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Bibliographische Detailangaben
Hauptverfasser: Jyh-Ping Chen, Pei-Chin Yang, Hwei-Fang Hwang
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Design methodology
Drugs
Iron
Medical treatment
Morphology
Nanoparticles
Radiative recombination
Spontaneous emission
SQUIDs
Superconducting magnets
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Zusammenfassung:Polyacrylic acid (PAA)-derivatized Fe 3 O 4 magnetic nanoparticle (MNP) intended as a drug carrier were synthesized by two different approaches and studied for chemicophysical properties. PAA-MNP prepared by physical adsorption of PAA on pre-formed MNP showed better properties for covalent binding with a thrombolytic drug, recombinant tissue plasminogen activator (rtPA). The PAA-MNP-rtPA conjugate showed full retention of thrombolytic activity and is useful as a magnetically targeted drug carrier to improve clinical thrombolytic therapy.
ISSN:2159-3523
DOI:10.1109/INEC.2010.5424830