3-D Near-Infrared Fluorescence Imaging Using an MEMS-Based Miniature Dual-Axis Confocal Microscope

We demonstrate a fast miniature microelectro-mechanical-system-based near-infrared fluorescence dual-axis confocal microscope in a 10-mm-diameter package for 3-D imaging in both ex vivo and in vivo samples. The miniature microscope, while in contact with the targeted tissue, can reveal subsurface st...

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Veröffentlicht in:	IEEE journal of selected topics in quantum electronics 2009-09, Vol.15 (5), p.1344-1350
Hauptverfasser:	Piyawattanametha, W., Hyejun Ra, Mandella, M.J., Loewke, K., Wang, T.D., Kino, G.S., Solgaard, O., Contag, C.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-D 3-D Biomedical materials Confocal dual-axis confocal (DAC) microscopy electrostatic actuation Electrostatic actuators en face endoscope Endoscopes endoscopy Fluorescence fluorescence imaging High-resolution imaging Humans Imaging In vivo In vivo tests Microelectromechanical systems microelectromechanical systems (MEMS) scanner microscope Microscopy Miniature mosaicing near-infrared fluorescence imaging Optical imaging real-time imaging self-alignment Spatial resolution Surgical implants vertical comb actuators
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Beschreibung
Zusammenfassung:	We demonstrate a fast miniature microelectro-mechanical-system-based near-infrared fluorescence dual-axis confocal microscope in a 10-mm-diameter package for 3-D imaging in both ex vivo and in vivo samples. The miniature microscope, while in contact with the targeted tissue, can reveal subsurface structure or anatomy as deep as 300 mum. The lateral and axial resolutions are 5 and 7 mum, respectively. Real-time en face mosaicing image of in vivo human skin is demonstrated to enlarge the overall FOV to be over 3 mm at acquisition frame rate of 5 frames/s.
ISSN:	1077-260X 1558-4542
DOI:	10.1109/JSTQE.2009.2021533