A method for normalizing histology slides for quantitative analysis

A method for normalizing histology slides for quantitative analysis

Inconsistencies in the preparation of histology slides make it difficult to perform quantitative analysis on their results. In this paper we provide two mechanisms for overcoming many of the known inconsistencies in the staining process, thereby bringing slides that were processed or stored under ve...

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Hauptverfasser: Macenko, M., Niethammer, M., Marron, J.S., Borland, D., Woosley, J.T., Xiaojun Guan, Schmitt, C., Thomas, N.E.
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Biological cells
Biomedical image processing
Biomedical microscopy
Biomedical signal detection
Deconvolution
Detectors
Diffraction
Fluorescence
Image retrieval
Information retrieval
Maximum likelihood estimation
Melanoma
Microscopy
Pathology
Testing
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Beschreibung
Zusammenfassung:Inconsistencies in the preparation of histology slides make it difficult to perform quantitative analysis on their results. In this paper we provide two mechanisms for overcoming many of the known inconsistencies in the staining process, thereby bringing slides that were processed or stored under very different conditions into a common, normalized space to enable improved quantitative analysis.
ISSN:1945-7928
1945-8452
DOI:10.1109/ISBI.2009.5193250