A novel SERS active particle with highly bio-organics absorption affinity for the description of bacteria fingerprint

A novel metal nanoparticles@mesoporous silicas with high surface area (ap 300 m 2 g -1 ), large pore size (> 5.0 nm) and high metal nanoparticles content (ap 10 wt.%) have been prepared and used as surface enhanced matrix for bacteria charectization under Raman scattering analysis. The prepared nanoparticles@mesoporous silicas present great adhesion ability to direct contact with microorganism, i.e. S. aureus. The characterized peak at 1523 cm -1 can be gradually enhanced from original 200 counts to 1000 and 4000 counts when Au content increased to 6% and 4%, respectively.