Production of nanocrystalline hydroxyapatite on collagen template during in vivo tooth and bone regeneration with use of collagen-Ca-phosphate preparations

Hydroxyapatite (hydroxyfluorapatite) - collagen and composite materials are synthesized using directed diffusion of ions from solutions on collagen fibers. Computer tomography indicates that the salt component is rather uniformly distributed over the organic matrix. According to the electron microscopic data,the composite materials involve salt nanocrystals (less than 1m in size), which are uniformly distributed between collagen fibers. Biotransformation of material was studied after its implantation to different defects of bones of experimental animals. Nanocrystals of apatite plays a role of some catalytic agent accelerating the regeneration process in studied bone, tooth tissues and parenchymatous organs.