Effects of Acute Hippocampal Stimulation on EEG Dynamics

Effects of Acute Hippocampal Stimulation on EEG Dynamics

Progressive preictal dynamical convergence and postictal divergence of dynamical EEG descriptors among brain regions has been reported in human temporal lobe epilepsy (TLE) and in a rodent model of TLE. There are also reports of anticonvulsant effects of high frequency stimulation of the hippocampus...

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Veröffentlicht in:2006 International Conference of the IEEE Engineering in Medicine and Biology Society 2006, Vol.2006, p.4382-4386
Hauptverfasser: Nair, S.P., Sackellares, J.C., Shiau, D.-S., Norman, W.M., Dance, L.K., Pardalos, P.M., Principe, J.C., Carney, P.R.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anticonvulsants - pharmacology
Brain modeling
Convergence
Electric Stimulation
Electrical stimulation
Electroencephalography
Electroencephalography - instrumentation
Electroencephalography - methods
Epilepsy
Epilepsy, Temporal Lobe - pathology
Epilepsy, Temporal Lobe - therapy
Equipment Design
Frequency
Hippocampus
Hippocampus - metabolism
Hippocampus - pathology
Humans
Male
Models, Statistical
Rats
Rodents
Seizures
Temporal lobe
Temporal Lobe - pathology
Time Factors
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Zusammenfassung:Progressive preictal dynamical convergence and postictal divergence of dynamical EEG descriptors among brain regions has been reported in human temporal lobe epilepsy (TLE) and in a rodent model of TLE. There are also reports of anticonvulsant effects of high frequency stimulation of the hippocampus in humans. We postulate that this anticonvulsant effect is due to dynamical resetting by the electrical stimulation. The following study investigated the effects of acute hippocampal electrical stimulation on dynamical transitions in the brain of a spontaneously seizing animal model of TLE to test the hypothesis of divergence in dynamical values by electrical stimulation of the hippocampus
ISSN:1557-170X
DOI:10.1109/IEMBS.2006.260830