A Portable Two-photon Fluorescence Microendoscope Based on a Two-dimensional Scanning Mirror

Towards overcoming the size limitations of conventional two-photon fluorescence microscopy for brain imaging in freely moving mice, we introduce a portable laser-scanning microendoscope based on a microelectromechanical systems (MEMS) two-dimensional (2-D) scanning mirror, compound gradient refracti...

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Hauptverfasser:	Piyawattanametha, W., Cocker, E.D., Barretto, R.P.J., Jung, J.C., Flusberg, B.A., Hyejun Ra, Solgaard, O., Schnitzer, M.J.
Format:	Tagungsbericht
Sprache:	eng
Schlagworte:	3-D image Brain Fiber lasers Fluorescence fluorescence image Mice Microelectromechanical systems Micromechanical devices Microscopy Mirrors Refractive index scanner scanning mirror Two dimensional displays two-photon
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Beschreibung
Zusammenfassung:	Towards overcoming the size limitations of conventional two-photon fluorescence microscopy for brain imaging in freely moving mice, we introduce a portable laser-scanning microendoscope based on a microelectromechanical systems (MEMS) two-dimensional (2-D) scanning mirror, compound gradient refractive index (GRIN) micro-lenses, and a photonic bandgap fiber (PBF). The microendoscope achieves fast line scanning acquisition rates up to 3.5 kHz and micron-scale imaging resolution.
ISSN:	2160-5033
DOI:	10.1109/OMEMS.2007.4373812