Behavioral Study of Calorie-restricted Rats from Early Old Age

Behavioral Study of Calorie-restricted Rats from Early Old Age

This paper aims to investigate the effect of Calorie Restriction (CR) on learning and memory ability of early aged rats. Methods: 18-month rats were subjected to restricted intake by 60% comparing with that of rats fed ad libitum (AL) for 6 months. We compared the overall health status, including su...

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Hauptverfasser: Geng, Y.Q., Guan, J.T., Xu, M.Y., Fu, Y.C.
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Aging
Animals
Behavior, Animal
Body Weight
Caloric Restriction
Chromium
Cognition
Data analysis
Delay
Energy Intake
Feeding Behavior
Locomotion
Male
Maze Learning
Memory
Navigation
Rats
Rats, Sprague-Dawley
Target tracking
Testing
Time Factors
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Beschreibung
Zusammenfassung:This paper aims to investigate the effect of Calorie Restriction (CR) on learning and memory ability of early aged rats. Methods: 18-month rats were subjected to restricted intake by 60% comparing with that of rats fed ad libitum (AL) for 6 months. We compared the overall health status, including survival rate and locomotor activity by open-field test. We examined the spatial cognition ability of the rats by Morris Water Maze.Our results showed that CR rats had higher survival rate and spontaneous locomotor activity compared with AL rats. CR rats slowed the inability of spatial learning and reference memory. These findings demonstrated that CR in early old rats delayed the declination of spatial cognition. I.
ISSN:1094-687X
1557-170X
1558-4615
DOI:10.1109/IEMBS.2007.4352809