A fuzzy confidence value for DNA bases

A fuzzy confidence value for DNA bases

A novel approach is presented for determining confidence values for bases called in DNA sequencing. The approach employs fuzzy logic, which forwards flexibility, adaptability and intuition through the use of linguistic variables and fuzzy membership. The proposed fuzzy logic-based method determines...

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Bibliographische Detailangaben
Hauptverfasser: Varghese, R.S., Musavi, M.T., Ressom, H.
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Applied sciences
Artificial intelligence
Computer science
control theory
systems
DNA computing
Error analysis
Exact sciences and technology
Fuzzy logic
Intelligent systems
Laboratories
Sequences
Signal analysis
Signal processing
Table lookup
Testing
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Beschreibung
Zusammenfassung:A novel approach is presented for determining confidence values for bases called in DNA sequencing. The approach employs fuzzy logic, which forwards flexibility, adaptability and intuition through the use of linguistic variables and fuzzy membership. The proposed fuzzy logic-based method determines the confidence values based on the height, the peakness, and the spacing of the first most likely candidate (the base called) and the peakness and height for the second likely candidate. The technique has been tested on over 3000 ABI 3700 DNA files and the result has shown improved performance over the existing Phred's and ABTs quality value.
ISSN:1098-7584
DOI:10.1109/FUZZY.2004.1375747