Association polymers for modulated release of bioactive proteins

The potential relevance for improving bone formation in and around tissue-engineered constructs. The objectives of this study were to investigate erosion and release of biologically active protein from CAP/PF-127 blends in an environment more representative of local growth factor delivery into a low...

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Veröffentlicht in:	IEEE engineering in medicine and biology magazine 2003-09, Vol.22 (5), p.35-41
Hauptverfasser:	Raiche, A.T., Puleo, D.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Biomimetic Materials - chemical synthesis Biomimetic Materials - chemistry Bones Cellulose - analogs & derivatives Cellulose - chemistry Coated Materials, Biocompatible - chemical synthesis Coated Materials, Biocompatible - chemistry Delayed-Action Preparations - chemistry Diffusion Drug Delivery Systems - instrumentation Drug Delivery Systems - methods Drug Implants - chemical synthesis Drug Implants - chemistry In vitro Materials Testing Microspheres Muramidase - administration & dosage Muramidase - chemistry Pistons Poloxamer - chemistry Polymers Protein engineering Proteins - administration & dosage Proteins - chemistry Spine Temperature Testing Thermal degradation Tissue Engineering - methods
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Beschreibung
Zusammenfassung:	The potential relevance for improving bone formation in and around tissue-engineered constructs. The objectives of this study were to investigate erosion and release of biologically active protein from CAP/PF-127 blends in an environment more representative of local growth factor delivery into a low clearance site. Within this study, effects of polymer blend ratio, sampling interval, and multilayering were examined with the ultimate goal of obtaining multiphasic release profiles over a period of several days.
ISSN:	0739-5175 1937-4186
DOI:	10.1109/MEMB.2003.1256270