Frequency of hepatitis delta virus in hepatitis B surface-antigen-positive patients

Objectives: The prevalence of hepatitis delta virus (HDV) worldwide shows geographical differences. Although there are several studies on anti-HDV seroprevalence rates in hepatitis B surface antigen (HBsAg)-positive patients in Turkey, studies on HDV-RNA prevalence in this patient population are lim...

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Veröffentlicht in:Viral hepatit dergisi 2019-04, Vol.25 (1), p.14-18
Hauptverfasser: Yolcu,Ayfer, Karabulut,Nuran, Alaçam,Sema, Önel,Mustafa, Büyük,Melek, Güllüoğlu,Mine, Ağaçfidan,Ali
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Sprache:eng
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Zusammenfassung:Objectives: The prevalence of hepatitis delta virus (HDV) worldwide shows geographical differences. Although there are several studies on anti-HDV seroprevalence rates in hepatitis B surface antigen (HBsAg)-positive patients in Turkey, studies on HDV-RNA prevalence in this patient population are limited. It was aimed to detect the frequency of anti-HDV antibodies and HDV-RNA in HBsAg-positive patients in this study. Materials and Methods: This retrospective study included 2089 HBsAg-positive patients in whom anti-HDV was analyzed between April 2015 and March 2017. Anti-HDV test was performed in serum samples obtained from HBsAg-positive patients by enzyme-linked immunosorbent assay. In anti-HDV-positive patients, HDV-RNA was analyzed in serum samples by real-time polymerase chain reaction. Results: The seroprevalence of anti-HDV was 4.1% (85/2089), while the rate of HDV-RNA positivity was 2.4% (51/2089). HDVRNA was detected in 60% (51/85) of anti-HDV-positive patients. The frequency of anti-HDV and HDV-RNA was highest in the 50-59 age group. Conclusion: The frequency of HDV in this study was found to be consistent with regional data. HDV viremia was detected in only 60% (51/85) of the anti-HDV-positive patients. Since anti-HDV antibodies may remain after recovery, it is important to investigate HDV-RNA to determine the true prevalence of HDV.
ISSN:1307-9441
2147-2939
DOI:10.4274/vhd.galenos.2018-0018