Relationship between interleukin-2 promoter polymorphism and preeclampsia

Purpose: One of the cytokines involved in the immune system is interleukin-2 (IL-2). It is contemplated that polymorphisms in the promoter region of the IL-2 gene may be one of the determining factors in the maternal immunization system associated with abnormal placentation resulting in preeclampsia. This study tried to determine the protective genotypes for preeclampsia by genotyping the -384 polymorphisms in the promoter region of interleukin 2 gene in preeclamptic Turkish women. Material and Methods: 146 blood samples, 57 normal and 89 preeclampsia, were collected from unrelated pregnant women. -384 promoter region of IL-2 gene is amplified by using PCR and Restriction Fragment Length Polymorphism method is applied by using Bfa-1 enzyme to identify the polymorphisms. Results: Of the 89 preeclamptic women included in the study, 38 had TT, 36 had GT, 15 had GG alleles and of the 57 normal pregnant women, 28 had TT, 22 had GT, and 7 had GG alleles. Conclusion: Considering the close relationship of preeclampsia with the immune system and the response to inflammation, this study aimed to investigate the relationship between IL-2 gene -384 promoter region polymorphism and preeclampsia. No statistically significant relationship was found between the genotypes. We think that comprehensive genetic studies including all negative factors that are effective for placenta formation would be useful.