Antimicrobial activity screening of a series of taurine derivatives

In this study, a series of taurinamide derivatives 1–18 were assessed for their in vitro antimicrobial activity. Enterococcus faecalis, which is the third most commonly isolated nosocomial pathogen among hospital infections, was found to be more susceptible to the tested compounds than other pathogens. Two of the tested compounds, 1 and 18, showed promising activity against E. faecalis, with minimal inhibitory concentrations (MICs) of 128 and 64 μg/mL, respectively. On the other hand, compound 3 was distinguished from other compounds by its better activity against G(−) Escherichia coli bacteria, with a MIC of 512 μg/mL. None of the compounds displayed better activity than the standard drugs Ciprofloxacin and Fluconazole.