Diyarbakır bölgesinde malign melanom hastalarının BRAF mutasyonu analizi

Purpose: The aim of this study was to determine BRAF V600E mutation rates of malignant melanoma (MM) cases in the Diyarbakır region in this study to investigate the relationship between mutation rate of prognostic parameters. We also aimed to compare the results with values from west Turkey. Materials and Methods: Between all cases of MM, including primary MM and metastatic MM diagnosed at Dicle University Medical Faculty Pathology Department between January 2014 and July 2019 were included. The BRAF V600E mutation results, which were studied with the real-time polyemerase chain reaction (PCR) method, were compared with the prognostic parameters. Results: In 93 patients with MM, the BRAF V600E mutation rate was 21.5% (n = 20). Trunk and head-neck tumors, cutaneous and mucosal tumors, Clark stage V tumors, tumors with a diameter of 0-2 mm, Ki-67 proliferation between 11-20%, non-ulcerous tumors, chronic sun exposure in a higher rate was detected. Conclusions: BRAF mutations in Diyarbakir region were found to be lower than the value in the region in the west of Turkey. We think that the reason for this is more frequent monitoring of acral lentiginous melanoma (ALM) in our region. Although the BRAF V600E mutation was observed more in small-sized tumors, it was seen more in high Clark stage tumors, suggesting that the mutation may occur later in the advanced stages of the tumor. Studies with high case series may reveal possible correlations between BRAF and prognostic values and may be useful in patient selection for treatment