Frontal Plane QRS-T Angle as a Marker of Cardiac Iron Overload in Patients with Beta Thalassemia Major

Introduction: Cardiomyopathy due to myocardial iron deposition is the leading cause of death in transfusion-dependent beta-thalassemia major (β-TM) patients. Although cardiac T2* magnetic resonance imaging (MRI) can be used for the early detection of cardiac iron level before the onset of symptoms a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Acta Cardiologica Sinica 2023-05, Vol.39 (3), p.406-415
Hauptverfasser: Görkem Kuş, Göksel Çağırcı, Nermin Bayar, Edip Can Özgünoğlu, Çağın Mustafa Üreyen, Ramazan Güven, Erdal Kurtoğlu, Şakir Arslan
Format: Artikel
Sprache:chi
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Introduction: Cardiomyopathy due to myocardial iron deposition is the leading cause of death in transfusion-dependent beta-thalassemia major (β-TM) patients. Although cardiac T2* magnetic resonance imaging (MRI) can be used for the early detection of cardiac iron level before the onset of symptoms associated with iron overload, this expensive method is not widely available in many hospitals. Frontal QRS-T angle is a novel marker of myocardial repolarization and is associated with adverse cardiac outcomes. We aimed to investigate the relationship between cardiac iron load and f(QRS-T) angle in patients with β-TM. Methods: The study included 95 β-TM patients. Cardiac T2* values under 20 were considered to indicate cardiac iron overload. The patients were divided into two groups according to the presence or absence of cardiac involvement. Laboratory and electrocardiography parameters, including frontal plane QRS-T angle, were compared between the two groups. Results: Cardiac involvement was detected in 33 (34%)
ISSN:1011-6842