溴化十六烷基三甲銨參與肝癌細胞上皮向間質轉換的分子機制

Liver cancer is one of the most common malignant tumors and is currently the fourth leading cause of cancerrelated mortality worldwide. Due to its rapid progression, the prognosis of patients with liver cancer is poor. Nowadays, alternative anticancer approaches or medicines should be explored to reduce the risk of disease progression. In particular, several studies have shown that cetrimonium bromide (CTAB) can be administered as a cytotoxic agent against some types of cancer by playing an anti-viability effect through a mitochondria-mediated apoptotic pathway. Nevertheless, our previous study demonstrated that CTAB played a strongly suppressive effect on the migration and invasion of different hepatocellular carcinoma (HCC) cell lines, such as SK-Hep1, Mahlavu, and HA22T/VGH cells. Specifically, CTAB was found to be involved in modulating canonical and non-canonical transforming growth factor-β (TGF-β), fibroblast growth factor (FGF), and c-Met/phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB, also kn