Insertion/Deletion Polymorphism of Angiotensin-Converting Enzyme Gene – Risk Factor for Coronary Artery Disease in the Tuzla Region Population (Bosnia and Herzegovina
Angiotensin II is the major effector molecule of renin-angiotensin system; its production can be conveniently interrupted by angiotensin-converting enzyme (ACE). Typical plasma levels of ACE accompany the I/D polymorphism; however, a controversy exists as to whether the DD genotype of the ACE polymo...
Gespeichert in:
Veröffentlicht in: | Collegium antropologicum 2003-12, Vol.27 (2), p.537 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Angiotensin II is the major effector molecule of renin-angiotensin system; its production
can be conveniently interrupted by angiotensin-converting enzyme (ACE). Typical
plasma levels of ACE accompany the I/D polymorphism; however, a controversy exists as
to whether the DD genotype of the ACE polymorphism affects the risk for the development
of coronary artery disease (CAD) and to what extent the ACE polymorphism is associated
with CAD in different populations. We compared the I/D polymorphism in 212
CAD patients younger than 50 years with 165 healthy control individuals. They were all
from the Tuzla region in Bosnia and Herzegovina. Patients with CAD had a higher prevalence
of the DD genotype (36.3%) than controls (25.6%). The odds ratio for the ACE
DD genotype in CAD patients was 1.7 (95% confidence interval 1.0–2.7; p |
---|---|
ISSN: | 0350-6134 1848-9486 |